abstract：:In this study, mapping of ultrashort T2 and T2* of acutely isolated porcine menisci at B0 = 9.4 T was investigated. Maps of T2 were measured from a slice through the pars intermedia with a spin echo-prepared two-dimensional ultrashort-TE T2 mapping technique published previously. T2* mapping was performed by two-dimen...

journal_title：NMR in biomedicine

authors： Kirsch S,Kreinest M,Reisig G,Schwarz ML,Ströbel P,Schad LR

更新日期：2013-09-01 00:00:00

abstract：:The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-ha...

journal_title：NMR in biomedicine

authors： Kim SG,Harel N,Jin T,Kim T,Lee P,Zhao F

更新日期：2013-08-01 00:00:00

abstract：:The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and ...

journal_title：NMR in biomedicine

authors： Tu C,Louie AY

更新日期：2013-07-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhi...

journal_title：NMR in biomedicine

authors： Zhang Y,Zhao H,Qiu S,Tian J,Wen X,Miller JL,von Deneen KM,Zhou Z,Gold MS,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:The majority of functional MRI studies of pain processing in the brain use the blood oxygenation level-dependent (BOLD) imaging approach. However, the BOLD signal is complex as it depends on simultaneous changes in blood flow, vascular volume and oxygen metabolism. Arterial spin labeling (ASL) perfusion imaging is ano...

journal_title：NMR in biomedicine

authors： Maleki N,Brawn J,Barmettler G,Borsook D,Becerra L

更新日期：2013-06-01 00:00:00

abstract：:We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exp...

journal_title：NMR in biomedicine

authors： Motaal AG,Coolen BF,Abdurrachim D,Castro RM,Prompers JJ,Florack LM,Nicolay K,Strijkers GJ

更新日期：2013-04-01 00:00:00

abstract：:Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CF,Liu HL,Lui CC,Huang YJ,Lee TH,Chang CC,Wang FN

更新日期：2013-04-01 00:00:00

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:The main aim of this study was to employ high-resolution MRI to investigate the spatiotemporal development of pathological features associated with contusive spinal cord injury (SCI) in mice. Experimental mice were subjected to either sham surgery or moderate contusive SCI. A 16.4-T small-animal MR system was employed...

journal_title：NMR in biomedicine

authors： Blomster LV,Cowin GJ,Kurniawan ND,Ruitenberg MJ

更新日期：2013-02-01 00:00:00

abstract：:The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently hampered by lack of reliable biomarkers. (1) H magnetic resona...

journal_title：NMR in biomedicine

authors： Coune PG,Craveiro M,Gaugler MN,Mlynárik V,Schneider BL,Aebischer P,Gruetter R

更新日期：2013-01-01 00:00:00

abstract：:The accuracy and precision of the quantification of metabolite concentrations in in vivo (1) H NMR spectroscopy are affected by linewidth and signal-to-noise ratio (SNR). To study the effect of both factors in in vivo (1) H NMR spectra acquired at ultrahigh field, a reference spectrum was generated by summing nine in ...

journal_title：NMR in biomedicine

authors： Hong ST,Pohmann R

更新日期：2013-01-01 00:00:00

abstract：:There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the...

journal_title：NMR in biomedicine

authors： Pudakalakatti SM,Uppangala S,D'Souza F,Kalthur G,Kumar P,Adiga SK,Atreya HS

更新日期：2013-01-01 00:00:00

abstract：:In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...

journal_title：NMR in biomedicine

authors： Grinberg F,Ciobanu L,Farrher E,Shah NJ

更新日期：2012-11-01 00:00:00

abstract：:Biomarkers of early response to treatment have the potential to improve cancer therapy by allowing treatment to be tailored to the individual. Alterations in lipids detected by in vivo MRS have been suggested as noninvasive biomarkers of cell stress and early indicators of cell death. An improved understanding of the ...

journal_title：NMR in biomedicine

authors： Mirbahai L,Wilson M,Shaw CS,McConville C,Malcomson RD,Kauppinen RA,Peet AC

更新日期：2012-11-01 00:00:00

abstract：:Metabolomic studies by NMR spectroscopy are increasingly employed for a variety of biomedical applications. A very standardized 1D proton NMR protocol is generally employed for data acquisition, associated with multivariate statistical tests. Even if targeted approaches have been proposed to quantify metabolites from ...

journal_title：NMR in biomedicine

authors： Martineau E,Tea I,Akoka S,Giraudeau P

更新日期：2012-08-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...

journal_title：NMR in biomedicine

authors： Choe AS,Stepniewska I,Colvin DC,Ding Z,Anderson AW

更新日期：2012-07-01 00:00:00

abstract：:The intimal and medial linings of the pulmonary artery consist largely of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), respectively. The migration of these cell types to a potential tissue-engineered pulmonary valve (TEPV) implant process is therefore of interest in understanding the val...

journal_title：NMR in biomedicine

authors： Ramaswamy S,Schornack PA,Smelko AG,Boronyak SM,Ivanova J,Mayer JE Jr,Sacks MS

更新日期：2012-03-01 00:00:00

abstract：:Nonbiological total disc replacement is currently being used for the treatment of intervertebral disc (IVD) disease and injury, but these implants are prone to mechanical wear, tear and possible dislodgement. Recently, tissue-engineered total disc replacement (TE-TDR) has been investigated as a possible alternative to...

journal_title：NMR in biomedicine

authors： Bowles RD,Gebhard HH,Dyke JP,Ballon DJ,Tomasino A,Cunningham ME,Härtl R,Bonassar LJ

更新日期：2012-03-01 00:00:00

abstract：:Vessel size index (VSI), a parameter related to the distribution of vessel diameters, may be estimated using two MRI approaches: (i) dynamic susceptibility contrast (DSC) MRI following the injection of a bolus of Gd-chelate. This technique is routinely applied in the clinic to assess intracranial tissue perfusion in p...

journal_title：NMR in biomedicine

authors： Pannetier N,Lemasson B,Christen T,Tachrount M,Troprès I,Farion R,Segebarth C,Rémy C,Barbier EL

更新日期：2012-02-01 00:00:00

abstract：:In this work we introduce the concept of correlation chemical shift imaging (CCSI). Novel CCSI pulse sequences are demonstrated on clinical scanners for two-dimensional Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) imaging experiments. To date there has been limited progress reported towar...

journal_title：NMR in biomedicine

authors： Andronesi OC,Gagoski BA,Adalsteinsson E,Sorensen AG

更新日期：2012-02-01 00:00:00

abstract：:At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...

journal_title：NMR in biomedicine

authors： Marjańska M,Auerbach EJ,Valabrègue R,Van de Moortele PF,Adriany G,Garwood M

更新日期：2012-02-01 00:00:00

abstract：:Increased sensitivity and chemical shift dispersion at ultra-high magnetic fields enable the precise quantification of an extended range of brain metabolites from (1)H MRS. However, all previous neurochemical profiling studies using single-voxel MRS at 7 T have been limited to data acquired from the occipital lobe wit...

journal_title：NMR in biomedicine

authors： Emir UE,Auerbach EJ,Van De Moortele PF,Marjańska M,Uğurbil K,Terpstra M,Tkáč I,Oz G

更新日期：2012-01-01 00:00:00

abstract：:In imaging of human lungs with hyperpolarised noble gases, measurements of apparent diffusion coefficient (ADC) and relaxation time provide valuable information for the assessment of lung microstructure. In this work, a sequence was developed for interleaved acquisition of ventilation images, ADC, T(2)* and flip angle...

journal_title：NMR in biomedicine

authors： Ajraoui S,Parra-Robles J,Marshall H,Deppe MH,Clemence M,Wild JM

更新日期：2012-01-01 00:00:00

abstract：:One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequen...

journal_title：NMR in biomedicine

authors： Near J,Simpson R,Cowen P,Jezzard P

更新日期：2011-12-01 00:00:00

abstract：:A novel polarizer based on the dissolution-dynamic nuclear polarization (DNP) method has been designed, built and tested. The polarizer differs from those previously described by being designed with sterile use intent and being compatible with clinical use. The main features are: (1) an integral, disposable fluid path...

journal_title：NMR in biomedicine

authors： Ardenkjaer-Larsen JH,Leach AM,Clarke N,Urbahn J,Anderson D,Skloss TW

更新日期：2011-10-01 00:00:00

abstract：:Bone contains a significant fraction of water that is not detectable with ordinary Cartesian imaging sequences. The advent of ultra-short echo-time (UTE) methods has allowed the recovery of this submillisecond T(2)* water. In this work, we have developed a new three-dimensional hybrid-radial ultra-short echo-time (3D ...

journal_title：NMR in biomedicine

authors： Rad HS,Lam SC,Magland JF,Ong H,Li C,Song HK,Love J,Wehrli FW

更新日期：2011-08-01 00:00:00

abstract：:High-energy phosphate metabolism, which allows the synthesis and regeneration of adenosine triphosphate (ATP), is a vital process for neuronal survival and activity. In particular, creatine kinase (CK) serves as an energy reservoir for the rapid buffering of ATP levels. Altered CK enzyme activity, reflecting compromis...

journal_title：NMR in biomedicine

authors： Jeong EK,Sung YH,Kim SE,Zuo C,Shi X,Mellon EA,Renshaw PF

更新日期：2011-08-01 00:00:00

abstract：:The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...

journal_title：NMR in biomedicine

authors： Snaar JE,Teeuwisse WM,Versluis MJ,van Buchem MA,Kan HE,Smith NB,Webb AG

更新日期：2011-08-01 00:00:00

abstract：:The processes of tumor invasion and metastasis have been well characterized at the molecular level, and numerous biomarkers of tumor aggressiveness have been discovered. Molecular imaging offers the opportunity to depict specific cell markers relevant to tumor aggressiveness. Here, we describe the role of MRI in ident...

journal_title：NMR in biomedicine

authors： McCann TE,Kosaka N,Turkbey B,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2011-07-01 00:00:00

abstract：:Early imaging or blood biomarkers of tumor response is needed to customize anti-tumor therapy on an individual basis. This study evaluates the sensitivity and relevance of five potential MRI biomarkers. Sixty nude rats were implanted with human glioma cells (U-87 MG) and randomized into three groups: one group receive...

journal_title：NMR in biomedicine

authors： Lemasson B,Christen T,Tizon X,Farion R,Fondraz N,Provent P,Segebarth C,Barbier EL,Genne P,Duchamp O,Remy C

更新日期：2011-06-01 00:00:00

abstract：:Quantitative magnetisation transfer imaging (qMTI) is an extension of conventional MT techniques and allows the measurement of parameters that reflect tissue ultrastructure through the properties of macromolecule-bound protons; these include the bound proton fraction and the relaxation times of free and bound proton p...

journal_title：NMR in biomedicine

authors： Tozer DJ,Rees JH,Benton CE,Waldman AD,Jäger HR,Tofts PS

更新日期：2011-06-01 00:00:00

abstract：:Diffusion tensor MRI (DTI) is a method for the noninvasive assessment of cellular organization and integrity in vivo. In this study, in vivo DTI was performed to demonstrate its ability to reflect photoreceptor cell alignment in adult C57BL/6 wild-type mice. Age-matched retinal degeneration 1 (rd1) mice were employed ...

journal_title：NMR in biomedicine

authors： Chen J,Wang Q,Chen S,Wickline SA,Song SK

更新日期：2011-06-01 00:00:00

abstract：:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...

journal_title：NMR in biomedicine

authors： Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha N

更新日期：2011-05-01 00:00:00

abstract：:Cross-talk between adipose tissue and liver is disturbed in the metabolic syndrome. Moreover, the relative fatty acid composition of adipose and liver fat is poorly characterized. Long-TE (1)H MRS can determine the unsaturation and polyunsaturation of adipose tissue. The aim of this study was to use long-TE (1)H MRS t...

journal_title：NMR in biomedicine

authors： Lundbom J,Hakkarainen A,Söderlund S,Westerbacka J,Lundbom N,Taskinen MR

更新日期：2011-04-01 00:00:00

abstract：:This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5  cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...

journal_title：NMR in biomedicine

authors： Chen JH,Mehta RS,Baek HM,Nie K,Liu H,Lin MQ,Yu HJ,Nalcioglu O,Su MY

更新日期：2011-04-01 00:00:00

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains p...

journal_title：NMR in biomedicine

authors： Wang K,van Meer MP,van der Marel K,van der Toorn A,Xu L,Liu Y,Viergever MA,Jiang T,Dijkhuizen RM

更新日期：2011-01-01 00:00:00

abstract：:Resolution enhancement for glutamate (Glu), glutamine (Gln) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7 T is reported. Sub-TE dependences of the multiplets of Glu, Gln, GSH, γ-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2.2-2.6 ppm were investigated wit...

journal_title：NMR in biomedicine

authors： Choi C,Dimitrov IE,Douglas D,Patel A,Kaiser LG,Amezcua CA,Maher EA

更新日期：2010-11-01 00:00:00

abstract：:Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...

journal_title：NMR in biomedicine

authors： Lipnick S,Liu X,Sayre J,Bassett LW,Debruhl N,Thomas MA

更新日期：2010-10-01 00:00:00